Neonatal Basophils Stifle the Function of Early-Life Dendritic Cells To Curtail Th1 Immunity in Newborn Mice.
J Immunol
; 195(2): 507-18, 2015 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-26034171
ABSTRACT
Neonatal immunity exhibits weak Th1 but excessive Th2 responses, and the underlying mechanisms remain elusive. In this article, we show that neonatal basophils readily produce IL-4, a cytokine that proved to be pivotal in shaping the programs of both lymphocyte subsets. Besides promoting Th2 programs, IL-4 is captured by the IL-4 heteroreceptor (IL-4Rα/IL-13Rα1) expressed on dendritic cells and instigates IL-12 downregulation. Under these circumstances, differentiating Th1 cells upregulate IL-13Rα1, leading to an unusual expression of the heteroreceptor, which will serve as a death marker for these Th1 cells during rechallenge with Ag. The resulting Th1/Th2 imbalance impacts childhood immunity culminating in sensitivity to allergic reactions, susceptibility to microbial infection and perhaps poor efficacy of pediatric vaccines.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Basófilos
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Células Dendríticas
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Células Th2
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Células Th1
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Regulação da Expressão Gênica no Desenvolvimento
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article