Effect on vascular permeability of a self-etching adhesive system containing an antimicrobial quaternary ammonium polymer QAMP into subcutaneous tissue of rats.
Arch Oral Biol
; 60(8): 1138-45, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26042623
ABSTRACT
OBJECTIVE:
This study investigated the effect of a self-etching adhesive system containing an antimicrobial quaternary ammonium methacrylate polymer (QAMP) on the vascular permeability using Evans blue and laser-Doppler flowmetric methods.DESIGN:
Forty rats were anesthetized and divided into groups saline solution; Clearfil™ Protect Bond; Clearfil™ SE Bond; Clearfil™ SE Bond containing QAMP. Injections of Evans blue were administrated intravenously and the substances were injected intradermally. Immediately before injection and after 3 and 6h, was evaluated the blood flow. The animals were killed 3 and 6h after injection. The dorsal skin was dissected and experimental sites were obtained. The vascular permeability was evaluated by dye extravasation area, the dye was extracted and absorbance measured.RESULTS:
Concerning the Evans blue method, Clearfil™ SE Bond containing QAMP showed an extravasation area statistically similar to Clearfil™ SE Bond and lower than Clearfil™ Protect Bond. No statistical difference was verified among experimental groups for the amount of dye extracted. Clearfil™ SE Bond containing QAMP provided better laser-Doppler flowmetric parameters than Clearfil™ Protect Bond immediately and 3h after injection.CONCLUSION:
The QAMP had lower effect on the exudative phase of the inflammatory process.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Permeabilidade Capilar
/
Adesivos Dentinários
/
Cimentos de Resina
/
Compostos de Amônio Quaternário
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article