Your browser doesn't support javascript.
loading
Selective inhibition of the hypoxia-inducible factor prolyl hydroxylase PHD3 by Zn(II).
Na, Yu-Ran; Woo, Dustin J; Choo, Hyunah; Chung, Hak Suk; Yang, Eun Gyeong.
Afiliação
  • Na YR; Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea. eunyang@kist.re.kr hschung@kist.re.kr.
Chem Commun (Camb) ; 51(53): 10730-3, 2015 Jul 07.
Article em En | MEDLINE | ID: mdl-26051901
ABSTRACT
We report herein that Zn(II) selectively inhibits the hypoxia-inducible factor prolyl hydroxylase PHD3 over PHD2, and does not compete with Fe(II). Independent of the oligomer formation induced by Zn(II), inhibition of the activity of PHD3 by Zn(II) involves Cys42 and Cys52 residues distantly located from the active site.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Zinco / Prolina Dioxigenases do Fator Induzível por Hipóxia / Inibidores de Prolil-Hidrolase Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Zinco / Prolina Dioxigenases do Fator Induzível por Hipóxia / Inibidores de Prolil-Hidrolase Idioma: En Ano de publicação: 2015 Tipo de documento: Article