Influence of renal complications on the efficacy and adverse events of tacrolimus combination therapy in patients with systemic lupus erythematosus (SLE) during a maintenance phase: a single-centre, prospective study.
Lupus Sci Med
; 2(1): e000091, 2015.
Article
em En
| MEDLINE
| ID: mdl-26056606
ABSTRACT
OBJECTIVES:
The study investigated whether renal complications affected the efficacy and safety of tacrolimus combination therapy in patients with systemic lupus erythematosus (SLE) during a maintenance phase.METHODS:
Fifty-seven patients with SLE (A 30 cases with renal complication, B 27 cases without renal complications) were included. The presence of renal complications was defined as proteinuria ≥0.5â g/day and lupus nephritis on renal biopsy. Major outcome measures included SLE disease activity index (SLEDAI), steroid dose, serum anti-dsDNA Ab, C3 and creatinine (Cr) levels and estimated glomerular filtration rate (eGFR). The patient's background factors included age, gender, disease duration and ACE-I/angiotensin II receptor blocker and statin therapies. We compared these outcome measures pre treatment and after 1â year of treatment.RESULTS:
The SLEDAI and serum C3 levels improved in both groups from pretreatment period to post-treatment period from 7.2±5.0 to 2.8±2.3 in A and 6.4±3.8 to 2.4±2.2 in B, p<0.001, and from 65.9±24.6 to 77.7±18.2â mg/dL in A and 81.8±23.0 to 90.6±19.4â mg/dL in B, p=0.002, respectively. The anti-dsDNA antibody level was reduced, and the serum Cr and eGFR levels were slightly elevated. No patients developed end-stage renal failure that required artificial dialysis.CONCLUSIONS:
Tacrolimus combination therapy had additive beneficial effects on reduced proteinuria and increased serum C3 levels in patients with SLE with renal complications during a maintenance phase.
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MEDLINE
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article