Discovery and Synthesis of a Novel Series of Liver X Receptor Antagonists.
Chem Pharm Bull (Tokyo)
; 63(8): 628-35, 2015.
Article
em En
| MEDLINE
| ID: mdl-26062802
ABSTRACT
Fourteen novel compounds were prepared and their antagonistic activities against liver X receptors (LXR) α/ß were tested in vitro. Compound 26 had an IC50 value of 6.4 µM against LXRα and an IC50 value of 5.6 µM against LXRß. Docking studies and the results of structure-activity relationships support the further development of this chemical series as LXRα/ß antagonists.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenofibrato
/
Receptores Nucleares Órfãos
/
Hipolipemiantes
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article