The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT).

Carpenter, Dale; Hsiang, Chinhui; Jiang, Xianzhi; Osorio, Nelson; BenMohamed, Lbachir; Jones, Clinton; Wechsler, Steven L

Carpenter, Dale; Hsiang, Chinhui; Jiang, Xianzhi; Osorio, Nelson; BenMohamed, Lbachir; Jones, Clinton; Wechsler, Steven L.

Afiliação

Carpenter D; Virology Research, Gavin Herbert Eye Institute and Department of Ophthalmology, School of Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
Hsiang C; Virology Research, Gavin Herbert Eye Institute and Department of Ophthalmology, School of Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
Jiang X; Virology Research, Gavin Herbert Eye Institute and Department of Ophthalmology, School of Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
Osorio N; Virology Research, Gavin Herbert Eye Institute and Department of Ophthalmology, School of Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
BenMohamed L; Virology Research, Gavin Herbert Eye Institute and Department of Ophthalmology, School of Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
Jones C; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute and Department of Ophthalmology, School of Medicine, University of California, Irvine, Irvine, CA, 92697, USA.
Wechsler SL; Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Irvine, CA, 92868-32013, USA.

J Neurovirol ; 21(5): 568-75, 2015 Oct.

Article em En | MEDLINE | ID: mdl-26071090

Assuntos

Apoptose/fisiologia; Herpes Simples/virologia; Herpesvirus Humano 1/fisiologia; MicroRNAs/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Latência Viral; Animais; Western Blotting; Linhagem Celular; Temperatura Baixa; Camundongos; Neurônios/metabolismo; Neurônios/virologia; Fosforilação; Ativação Viral/fisiologia; Latência Viral/fisiologia

Palavras-chave

AKT; Cold-shock-induced apoptosis; Herpes simplex virus type 1; Latency-associated transcript

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Latência Viral / Herpesvirus Humano 1 / MicroRNAs / Proteínas Proto-Oncogênicas c-akt / Herpes Simples Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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