Nuclear envelope: positioning nuclei and organizing synapses.
Curr Opin Cell Biol
; 34: 84-93, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-26079712
ABSTRACT
The nuclear envelope plays an essential role in nuclear positioning within cells and tissues. This review highlights advances in understanding the mechanisms of nuclear positioning during skeletal muscle and central nervous system development. New findings, particularly about A-type lamins and Nesprin1, may link nuclear envelope integrity to synaptic integrity. Thus synaptic defects, rather than nuclear mispositioning, may underlie human pathologies associated with mutations of nuclear envelope proteins.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Membrana Nuclear
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article