Mechanistic and Kinetic Insight into Spontaneous Cocrystallization of Isoniazid and Benzoic Acid.

Sarcevica, Inese; Orola, Liana; Nartowski, Karol P; Khimyak, Yaroslav Z; Round, Andrew N; Fábián, László

Sarcevica, Inese; Orola, Liana; Nartowski, Karol P; Khimyak, Yaroslav Z; Round, Andrew N; Fábián, László.

Afiliação

Sarcevica I; Department of Chemistry, University of Latvia, K.Valdemara street 48, Riga LV1013, Latvia.
Orola L; School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, U.K.
Nartowski KP; Department of Chemistry, University of Latvia, K.Valdemara street 48, Riga LV1013, Latvia.
Khimyak YZ; School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, U.K.
Round AN; School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, U.K.
Fábián L; School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, U.K.

Mol Pharm ; 12(8): 2981-92, 2015 Aug 03.

Article em En | MEDLINE | ID: mdl-26086552

Assuntos

Ácido Benzoico/química; Química Farmacêutica; Cristalização/métodos; Isoniazida/química; Estabilidade de Medicamentos; Cinética; Solubilidade; Termodinâmica; Difração de Raios X

Palavras-chave

Cocrystallization; effect of spinning; mechanochemistry; solid-state kinetics; spontaneous reactions

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Química Farmacêutica / Ácido Benzoico / Cristalização / Isoniazida Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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