Compromised immune response in infants at risk for type 1 diabetes born by Caesarean Section.
Clin Immunol
; 160(2): 282-5, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26111479
ABSTRACT
Children born by Caesarean Section have a higher risk for type 1 diabetes. We aimed to investigate whether Caesarean Section leads to alterations of the immune response in children with familial risk for type 1 diabetes. We examined measures of innate and adaptive immune responses in 94 prospectively followed children, including 40 born by Caesarean Section. Proinflammatory serum cytokine concentrations were determined at age 6 months. As a measure of vaccine response, IgG1, IgG2, and IgG4 tetanus antibody titers and CD4(+) T cell proliferation against tetanus toxoid were quantified. Compared to infants born by vaginal delivery, infants born by Caesarean Section had lower concentrations of the cytokines IFN-É£ (p=0.014) and IL-8 (p=0.005), and weaker CD4(+) T cell responses to tetanus measured in the first (p=0.007) and second year (p=0.047) of life. Overall, our findings provide evidence that the mode of delivery influences the immune status and responsiveness during childhood.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Toxoide Tetânico
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Cesárea
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Interleucina-8
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Interferon gama
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Diabetes Mellitus Tipo 1
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Imunidade Adaptativa
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article