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Discovery of 2-arylamino-4-(1-methyl-3-isopropylsulfonyl-4-pyrazol-amino)pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors.
Zhang, Peilong; Dong, Jiaqiang; Zhong, Boyu; Zhang, Deyi; Jin, Can; Meng, Xuejing; Sun, Desheng; Xu, Xiangyuan; Zhou, Yong; Liang, Zhi; Ji, Minghua; Li, Hailong; Xu, Tao; Song, Guowei; Zhang, Ling; Chen, Gang; Yuan, Hongbin; Shih, Joe; Zhang, Ruihao; Hou, Guojun; Jin, Ying; Yang, Qiong.
Afiliação
  • Zhang P; Department of Applied Chemistry, Beijing Institute of Technology, Zhongguancun South Street, Beijing 100081, China; Beijing Pearl Biotech Ltd, No. 203, Section 2, Wangjing Lize Zhongyuan, Chaoyang District, Beijing 100102, China.
  • Dong J; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China. Electronic address: dongjiaqiang@crownbio.com.
  • Zhong B; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Zhang D; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Jin C; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Meng X; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Sun D; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Xu X; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Zhou Y; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Liang Z; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Ji M; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Li H; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Xu T; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Song G; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Zhang L; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Chen G; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Yuan H; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Shih J; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Zhang R; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Hou G; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Jin Y; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
  • Yang Q; Crown Bioscience Inc. (Taicang), 6 Beijing West Road, Taicang Economic Development Area, Taicang 215400, China.
Bioorg Med Chem Lett ; 25(17): 3738-43, 2015 Sep 01.
Article em En | MEDLINE | ID: mdl-26130408
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Receptores Proteína Tirosina Quinases / Inibidores de Proteínas Quinases / Antineoplásicos Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Receptores Proteína Tirosina Quinases / Inibidores de Proteínas Quinases / Antineoplásicos Idioma: En Ano de publicação: 2015 Tipo de documento: Article