Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes.

Berti, Lucia; Irmler, Martin; Zdichavsky, Marty; Meile, Tobias; Böhm, Anja; Stefan, Norbert; Fritsche, Andreas; Beckers, Johannes; Königsrainer, Alfred; Häring, Hans-Ulrich; de Angelis, Martin Hrabe; Staiger, Harald

Berti, Lucia; Irmler, Martin; Zdichavsky, Marty; Meile, Tobias; Böhm, Anja; Stefan, Norbert; Fritsche, Andreas; Beckers, Johannes; Königsrainer, Alfred; Häring, Hans-Ulrich; de Angelis, Martin Hrabe; Staiger, Harald.

Afiliação

Berti L; Institute of Experimental Genetics, Helmholtz Centre Munich GmbH, German Research Centre for Environmental Health, Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany ; German Centre for Diabetes Research (DZD), Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany.
Irmler M; Institute of Experimental Genetics, Helmholtz Centre Munich GmbH, German Research Centre for Environmental Health, Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany ; German Centre for Diabetes Research (DZD), Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany.
Zdichavsky M; Department of General, Visceral and Transplant Surgery, University Hospital Tübingen, Hoppe-Seyler-Straße 3, D-72076 Tübingen, Germany.
Meile T; Department of General, Visceral and Transplant Surgery, University Hospital Tübingen, Hoppe-Seyler-Straße 3, D-72076 Tübingen, Germany.
Böhm A; German Centre for Diabetes Research (DZD), Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany ; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Otfried-Müller-Straße 10, D-72076 Tübingen, Germany ; Department of Internal Medici
Stefan N; German Centre for Diabetes Research (DZD), Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany ; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Otfried-Müller-Straße 10, D-72076 Tübingen, Germany ; Department of Internal Medici
Fritsche A; German Centre for Diabetes Research (DZD), Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany ; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Otfried-Müller-Straße 10, D-72076 Tübingen, Germany ; Department of Internal Medici
Beckers J; Institute of Experimental Genetics, Helmholtz Centre Munich GmbH, German Research Centre for Environmental Health, Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany ; German Centre for Diabetes Research (DZD), Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany ; Chair for Experimental Genet
Königsrainer A; Department of General, Visceral and Transplant Surgery, University Hospital Tübingen, Hoppe-Seyler-Straße 3, D-72076 Tübingen, Germany.
Häring HU; German Centre for Diabetes Research (DZD), Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany ; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Otfried-Müller-Straße 10, D-72076 Tübingen, Germany ; Department of Internal Medici
de Angelis MH; Institute of Experimental Genetics, Helmholtz Centre Munich GmbH, German Research Centre for Environmental Health, Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany ; German Centre for Diabetes Research (DZD), Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany ; Chair for Experimental Genet
Staiger H; German Centre for Diabetes Research (DZD), Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany ; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Otfried-Müller-Straße 10, D-72076 Tübingen, Germany ; Department of Internal Medici

Mol Metab ; 4(7): 519-27, 2015 Jul.

Article em En | MEDLINE | ID: mdl-26137439

Palavras-chave

AMPK, AMP-activated protein kinase; Adipokine; Adiponectin; BMI, body mass index; C/EBP-α, CCAAT/enhancer-binding protein-α; CIDEA, cell death-inducing DNA fragmentation factor-like effector a; ERK, extracellular signal-regulated kinase; FGF, fibroblast growth factor; FGF21; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; Hepatokine; IL-6, interleukin-6; MHO, metabolically healthy obesity; MUHO, metabolically unhealthy obesity; PGC-1α, PPAR-Î³ coactivator-1α; PPAR-Î³, peroxisome proliferator-activated receptor-Î³; Secretome; Type-2 diabetes; UCP-1, uncoupling protein-1; hasc, human abdominal subcutaneous; qPCR, quantitative polymerase chain reaction; rh, recombinant human

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