Non-infectious aortitis of the ascending aorta: a histological and clinical correlation of 71 cases including overlap with medial degeneration and atheroma--a challenge for the pathologist.
J Clin Pathol
; 68(11): 898-904, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26152734
ABSTRACT
AIMS:
Aortitis is a rare but important cause of thoracic aortic disease. We describe its histopathological patterns and associations with other aortic pathologies and systemic inflammatory disease.METHODS:
Database searches of thoracic specimens over 17 years from two centres yielded 71 cases of non-infectious aortitis. Histological verification of tunica media inflammation was required for inclusion. Clinical information and histopathological features were recorded.RESULTS:
Three histological patterns emerged--necrotising aortitis with giant cells (53), diffuse band-like aortitis (16) and 'other' (2). 50/53 cases of necrotising aortitis with giant cells were isolated/idiopathic, while 9/16 cases of diffuse aortitis had a systemic inflammatory disease. Medial degeneration (MD) was prominent in 23/71 cases--all in the necrotising aortitis with giant cells category.CONCLUSIONS:
Non-infectious aortitis is predominantly idiopathic/isolated in nature, occurring in elderly females. Two patterns emerge--(1) necrotising aortitis with giant cells, which is more likely to be idiopathic and linked to MD, suggesting a possible aetiological relationship; and (2) diffuse aortitis, which is linked to an increased risk of systemic inflammatory disease. Knowledge, therefore, of histopathological patterns may guide patient management and follow-up.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Aorta
/
Aortite
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article