The prognostic value of plasma thrombospondin-1 concentrations after aneurysmal subarachnoid hemorrhage.
Clin Chim Acta
; 448: 155-60, 2015 Aug 25.
Article
em En
| MEDLINE
| ID: mdl-26162270
ABSTRACT
BACKGROUND:
Thrombospondin-1 is a homotrimeric glycoprotein with well known functions in hemostasis and angiogenesis. Its expression was increased after experimental intracerebral hemorrhage. We determined whether increased plasma thrombospondin-1 concentrations are predictive of clinical outcomes of aneurysmal subarachnoid hemorrhage (aSAH).METHODS:
Plasma thrombospondin-1 concentrations of 118 aSAH patients and 118 age- and gender-matched healthy controls were determined using enzyme-linked immunosorbent assay. Patients were followed up until death or completion of 6months after aSAH. An unfavorable outcome was defined as Glasgow Outcome Scale score of 1-3. Multivariate analyses of significant variables of univariate analyses were performed to determine independent risk factors for the clinical outcomes.RESULTS:
Plasma thrombospondin-1 concentrations were significantly higher in aSAH patients than in healthy controls; plasma thrombospondin-1 concentrations were independently associated with clinical severity reflected by the World Federation of Neurological Surgeons score and Fisher score; thrombospondin-1 was identified as an independent predictor of 6-month mortality and 6-month unfavorable outcome; thrombospondin-1 had similar predictive performance compared with the World Federation of Neurological Surgeons score and Fisher score according to receiver operating characteristic curve analysis.CONCLUSION:
Higher plasma thrombospondin-1 concentrations are associated with clinical severity and long-term prognosis of aSAH patients.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Hemorragia Subaracnóidea
/
Trombospondina 1
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article