A novel natural compound from garlic (Allium sativum L.) with therapeutic effects against experimental polymicrobial sepsis.
Biochem Biophys Res Commun
; 464(3): 774-9, 2015 Aug 28.
Article
em En
| MEDLINE
| ID: mdl-26166823
ABSTRACT
Sepsis is a serious, life-threatening, infectious disease. In this study, we demonstrate that sucrose methyl 3-formyl-4-methylpentanoate (SMFM), a novel natural compound isolated from garlic (Allium sativum L.), markedly enhances survival rates by inhibiting lung inflammation in a cecal ligation and puncture (CLP) experimental polymicrobial sepsis model. SMFM strongly reduced bacterial colony units from peritoneal fluid in CLP mice by stimulating the generation of reactive oxygen species. Lymphocyte apoptosis in spleens from CLP mice was also markedly decreased by SMFM administration. SMFM also significantly inhibited the production of proinflammatory cytokines, such as TNF-α, interleukin-1ß (IL-1ß) and IL-6, in CLP mice. Lipopolysaccharide-stimulated production of TNF-α and IL-6 were also strongly inhibited by SMFM in mouse bone marrow-derived macrophages. Taken together, our results indicate that SMFM has therapeutic effects against polymicrobial sepsis that are mediated by enhanced microbial killing and blockage of cytokine storm.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sacarose
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Sepse
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Alho
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Anti-Infecciosos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article