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Simultaneous PET/MRI in stroke: a case series.
Werner, Peter; Saur, Dorothee; Zeisig, Vilia; Ettrich, Barbara; Patt, Marianne; Sattler, Bernhard; Jochimsen, Thies; Lobsien, Donald; Meyer, Philipp M; Bergh, Florian Then; Dreyer, Antje; Boltze, Johannes; Classen, Joseph; Fritzsch, Dominik; Hoffmann, Karl-Titus; Sabri, Osama; Barthel, Henryk.
Afiliação
  • Werner P; Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
  • Saur D; Department of Neurology, University of Leipzig, Leipzig, Germany.
  • Zeisig V; Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
  • Ettrich B; Department of Neurology, University of Leipzig, Leipzig, Germany.
  • Patt M; Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
  • Sattler B; Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
  • Jochimsen T; Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
  • Lobsien D; Department of Neuroradiology, University of Leipzig, Leipzig, Germany.
  • Meyer PM; Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
  • Bergh FT; Department of Neurology, University of Leipzig, Leipzig, Germany.
  • Dreyer A; Translational Centre for Regenerative Medicine, University Hospital Leipzig, University of Leipzig, Leipzig, Germany.
  • Boltze J; Translational Centre for Regenerative Medicine, University Hospital Leipzig, University of Leipzig, Leipzig, Germany.
  • Classen J; Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.
  • Fritzsch D; Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.
  • Hoffmann KT; Massachusetts General Hospital and Harvard Medical School, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts, USA.
  • Sabri O; Department of Neurology, University of Leipzig, Leipzig, Germany.
  • Barthel H; Department of Neuroradiology, University of Leipzig, Leipzig, Germany.
J Cereb Blood Flow Metab ; 35(9): 1421-5, 2015 Sep.
Article em En | MEDLINE | ID: mdl-26174332
ABSTRACT
Prospective studies on magnetic resonance imaging (MRI)-guided systemic thrombolysis >4.5 hours after stroke onset did not reach their primary end points. It was discussed and observed in post hoc data re-assessment that this was partly because of limited MRI accuracy to measure critical hypoperfusion. We report the first cases of simultaneous [(15)O]H2O-positron emission tomography (PET)/MRI in stroke patients and an ovine model. Discrepancies between simultaneously obtained PET and MRI readouts were observed that might explain the above current limitations of stroke MRI. By offering highly complementary information, [(15)O]H2O-PET/MRI might help to identify critically hypoperfused tissue resulting in an improved patient stratification in thrombolysis trials.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Imageamento por Ressonância Magnética / Acidente Vascular Cerebral / Tomografia por Emissão de Pósitrons Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Imageamento por Ressonância Magnética / Acidente Vascular Cerebral / Tomografia por Emissão de Pósitrons Idioma: En Ano de publicação: 2015 Tipo de documento: Article