Electrical impedance myography discriminates congenital muscular dystrophy from controls.
Muscle Nerve
; 53(3): 402-6, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26179210
ABSTRACT
INTRODUCTION:
Electrical impedance myography (EIM) is an emerging non-invasive, highly reproducible electrophysiological technique that objectively characterizes muscle structure and composition by measuring bioimpedance. We assessed the ability of EIM ability to discriminate 2 forms of congenital muscular dystrophy (CMD), laminin α2 (LAMA2)-deficient CMD and collagen VI-deficient (COL6) CMD, from a group of healthy children. We also investigated correlations between subcutaneous fat thickness and EIM parameters.METHODS:
Twenty-eight children with LAMA2 CMD (n = 12) or COL6 (n = 16) CMD and 18 normal children underwent EIM testing.RESULTS:
The EIM 50-kHz phase was decreased in LAMA2 and COL6 CMD when compared with controls (P < 0.001). Reactance, however, was decreased in COL6 but not LAMA2 CMD compared with controls (P < 0.001).CONCLUSIONS:
Our findings suggest that EIM may be useful in discriminating CMD from controls and may serve as a useful biomarker to follow disease progression in clinical trials.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Impedância Elétrica
/
Distrofias Musculares
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article