Intrinsic Frequency and the Single Wave Biopsy: Implications for Insulin Resistance.
J Diabetes Sci Technol
; 9(6): 1246-52, 2015 Jul 16.
Article
em En
| MEDLINE
| ID: mdl-26183600
ABSTRACT
Insulin resistance is the hallmark of classical type II diabetes. In addition, insulin resistance plays a central role in metabolic syndrome, which astonishingly affects 1 out of 3 adults in North America. The insulin resistance state can precede the manifestation of diabetes and hypertension by years. Insulin resistance is correlated with a low-grade inflammatory condition, thought to be induced by obesity as well as other conditions. Currently, the methods to measure and monitor insulin resistance, such as the homeostatic model assessment and the euglycemic insulin clamp, can be impractical, expensive, and invasive. Abundant evidence exists that relates increased pulse pressure, pulse wave velocity (PWV), and vascular dysfunction with insulin resistance. We introduce a potential method of assessing insulin resistance that relies on a novel signal-processing algorithm, the intrinsic frequency method (IFM). The method requires a single pulse pressure wave, thus the term " wave biopsy."
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MEDLINE
Assunto principal:
Aorta
/
Doenças Vasculares
/
Resistência à Insulina
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Síndrome Metabólica
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Rigidez Vascular
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Análise de Onda de Pulso
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Pressão Arterial
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article