Catalytic dehydrogenative N-((triisopropylsilyl)oxy)carbonyl (Tsoc) protection of amines using iPr3SiH and CO2.

Tanaka, S; Yamamura, T; Nakane, S; Kitamura, M

Tanaka, S; Yamamura, T; Nakane, S; Kitamura, M.

Afiliação

Tanaka S; Graduate School of Pharmaceutical Sciences, Graduate School of Science, and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8601, Japan. kitamura@os.rcms.nagoya-u.ac.jp.

Chem Commun (Camb) ; 51(66): 13110-2, 2015 Aug 25.

Article em En | MEDLINE | ID: mdl-26185913

ABSTRACT

ABSTRACT

A versatile method has been found to catalyze the dehydrogenative N-((triisopropylsilyl)oxy)carbonyl (Tsoc) protection of amines using Pd/C, volatile iPr3SiH and CO2 gas without the liberation of any salts. A simple filtration/evaporation process facilitates the easy isolation of the product, thereby enhancing the utility of Tsoc as an amine-protecting group in organic synthesis.

Assuntos

Aminas/química; Dióxido de Carbono/química; Compostos de Trimetilsilil/química; Catálise; Hidrogenação

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Trimetilsilil / Dióxido de Carbono / Aminas Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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