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Impact of Age and Primary Disease Site on Outcome in Women With Low-Grade Serous Carcinoma of the Ovary or Peritoneum: Results of a Large Single-Institution Registry of a Rare Tumor.
Gershenson, David M; Bodurka, Diane C; Lu, Karen H; Nathan, Lisa C; Milojevic, Ljiljana; Wong, Kwong K; Malpica, Anais; Sun, Charlotte C.
Afiliação
  • Gershenson DM; All authors: University of Texas MD Anderson Cancer Center, Houston, TX. dgershen@mdanderson.org.
  • Bodurka DC; All authors: University of Texas MD Anderson Cancer Center, Houston, TX.
  • Lu KH; All authors: University of Texas MD Anderson Cancer Center, Houston, TX.
  • Nathan LC; All authors: University of Texas MD Anderson Cancer Center, Houston, TX.
  • Milojevic L; All authors: University of Texas MD Anderson Cancer Center, Houston, TX.
  • Wong KK; All authors: University of Texas MD Anderson Cancer Center, Houston, TX.
  • Malpica A; All authors: University of Texas MD Anderson Cancer Center, Houston, TX.
  • Sun CC; All authors: University of Texas MD Anderson Cancer Center, Houston, TX.
J Clin Oncol ; 33(24): 2675-82, 2015 Aug 20.
Article em En | MEDLINE | ID: mdl-26195696
ABSTRACT

PURPOSE:

Low-grade serous carcinoma of the ovary (LGSOC) or peritoneum (LGSPC) is a rare subtype of ovarian or peritoneal cancer characterized by young age at diagnosis and relative resistance to chemotherapy. The purpose of this study is to report our updated experience with women diagnosed with LGSOC or LGSPC to assess the validity of our original observations. PATIENTS AND

METHODS:

Eligibility criteria for patients from our database were stage I to IV LGSOC or LGSPC, original diagnosis before January 2012, and adequate clinical information. All patients were included in progression-free survival, overall survival, and multivariable Cox regression analyses. A subset analysis was performed among patients with stage II to IV low-grade serous carcinoma treated with primary surgery followed by platinum-based chemotherapy.

RESULTS:

We identified 350 eligible patients. Median progression-free survival was 28.1 months; median overall survival was 101.7 months. In the multivariable analysis, compared with women age ≤ 35 years, those diagnosed at age > 35 years had a 43% reduction in likelihood of dying (hazard ratio, 0.53; 95% CI, 0.37 to 0.74; P < .001). Having disease present at completion of primary therapy was associated with a 1.78 increased hazard of dying compared with being clinically disease free (P < .001). Similar trends were noted in the smaller patient cohort. In this cohort, women with LGSPC had a 41% decreased chance of dying (hazard ratio, 0.59; 95% CI, 0.36 to 0.98; P = .04) compared with those with LGSOC.

CONCLUSION:

Women age < 35 years with low-grade serous carcinoma and those with persistent disease at completion of primary therapy have the worst outcomes. Patients with LGSPC seem to have a better prognosis than those with LGSOC.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Neoplasias Peritoneais / Cistadenocarcinoma Seroso Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Neoplasias Peritoneais / Cistadenocarcinoma Seroso Idioma: En Ano de publicação: 2015 Tipo de documento: Article