A bioinspired catalytic aerobic oxidative C-H functionalization of primary aliphatic amines: synthesis of 1,2-disubstituted benzimidazoles.
Chemistry
; 21(36): 12606-10, 2015 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-26206475
ABSTRACT
Aerobic oxidative CH functionalization of primary aliphatic amines has been accomplished with a biomimetic cooperative catalytic system to furnish 1,2-disubstituted benzimidazoles that play an important role as drug discovery targets. This one-pot atom-economical multistep process, which proceeds under mild conditions, with ambient air and equimolar amounts of each coupling partner, constitutes a convenient environmentally friendly strategy to functionalize non-activated aliphatic amines that remain challenging substrates for non-enzymatic catalytic aerobic systems.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Benzimidazóis
/
Aminas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article