A putative amino acid ABC transporter substrate-binding protein, NMB1612, from Neisseria meningitidis, induces murine bactericidal antibodies against meningococci expressing heterologous NMB1612 proteins.

Hung, Miao-Chiu; Humbert, María Victoria; Laver, Jay R; Phillips, Renee; Heckels, John E; Christodoulides, Myron

Hung, Miao-Chiu; Humbert, María Victoria; Laver, Jay R; Phillips, Renee; Heckels, John E; Christodoulides, Myron.

Afiliação

Hung MC; Neisseria Research, Molecular Microbiology, Division of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Medical School, Southampton SO166YD, United Kingdom.
Humbert MV; Neisseria Research, Molecular Microbiology, Division of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Medical School, Southampton SO166YD, United Kingdom.
Laver JR; Neisseria Research, Molecular Microbiology, Division of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Medical School, Southampton SO166YD, United Kingdom.
Phillips R; Neisseria Research, Molecular Microbiology, Division of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Medical School, Southampton SO166YD, United Kingdom.
Heckels JE; Neisseria Research, Molecular Microbiology, Division of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Medical School, Southampton SO166YD, United Kingdom.
Christodoulides M; Neisseria Research, Molecular Microbiology, Division of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Medical School, Southampton SO166YD, United Kingdom. Electronic address: mc4@soton.ac.uk.

Vaccine ; 33(36): 4486-94, 2015 Aug 26.

Article em En | MEDLINE | ID: mdl-26207592

Assuntos

Transportadores de Cassetes de Ligação de ATP/imunologia; Anticorpos Antibacterianos/sangue; Proteínas de Bactérias/imunologia; Atividade Bactericida do Sangue; Imunidade Heteróloga; Vacinas Meningocócicas/imunologia; Neisseria meningitidis Sorogrupo B/imunologia; Transportadores de Cassetes de Ligação de ATP/genética; Adjuvantes Imunológicos/administração & dosagem; Hidróxido de Alumínio/administração & dosagem; Animais; Proteínas de Bactérias/genética; Clonagem Molecular; Reações Cruzadas; Escherichia coli/genética; Escherichia coli/metabolismo; Expressão Gênica; Humanos; Lipossomos/administração & dosagem; Vacinas Meningocócicas/administração & dosagem; Vacinas Meningocócicas/genética; Camundongos Endogâmicos BALB C; Neisseria meningitidis Sorogrupo B/genética; Coelhos; Vacinas Sintéticas/administração & dosagem; Vacinas Sintéticas/genética; Vacinas Sintéticas/imunologia

Palavras-chave

Amino acid ABC transporter; Bactericidal activity; Meningococcal vaccine; Neisseria meningitidis; Sequence diversity; Substrate-binding protein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Atividade Bactericida do Sangue / Transportadores de Cassetes de Ligação de ATP / Vacinas Meningocócicas / Neisseria meningitidis Sorogrupo B / Imunidade Heteróloga / Anticorpos Antibacterianos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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