Carpal erosions in children with juvenile idiopathic arthritis: repeatability of a newly devised MR-scoring system.
Pediatr Radiol
; 45(13): 1972-80, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26209959
ABSTRACT
BACKGROUND:
Juvenile idiopathic arthritis (JIA) is characterized by synovial inflammation, with potential risk of developing progressive joint destruction. Personalized state-of-the-art treatment depends on valid markers for disease activity to monitor response; however, no such markers exist.OBJECTIVE:
To evaluate the reliability of scoring of carpal bone erosions on MR in children with JIA using two semi-quantitative scoring systems. MATERIALS ANDMETHODS:
A total of 1,236 carpal bones (91 MR wrist examinations) were scored twice by two independent pediatric musculoskeletal radiologists. Bony erosions were scored according to estimated bone volume loss using a 0-4 scale and a 0-10 scale. An aggregate erosion score comprising the sum total carpal bone volume loss was calculated for each examination.RESULTS:
The 0-4 scoring system resulted in good intra-reader agreement and moderate to good inter-observer agreement in the assessment of individual bones. Fair and moderate agreement were achieved for inter-reader and intra-reader agreement, respectively, using the 0-10 scale. Intra- and particularly inter-reader aggregate score variability were much less favorable, with wide limits of agreement.CONCLUSION:
Further analysis of erosive disease patterns compared with normal subjects is required, and to facilitate the development of an alternative means of quantifying disease.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Artrite Juvenil
/
Imageamento por Ressonância Magnética
/
Ossos do Carpo
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article