Peroxisome Proliferator-Activated Receptor-γ and Its Ligands in the Treatment of Tumors in the Nervous System.
Curr Stem Cell Res Ther
; 11(3): 208-15, 2016.
Article
em En
| MEDLINE
| ID: mdl-26216127
ABSTRACT
The peroxisome proliferator-activated receptor -γ (PPARγ) has been identified in a wide range of cancers, including brain, breast, colon, stomach and lung cancers. It belongs to the thyroid/ steroid hormone receptors superfamily. Binding with their special ligands, PPARγ plays important roles in regulating transcription of their target genes. PPARγ activation suppresses the growth of the tumor cells, implicating the anti-tumor potential of PPARγ ligand. Tumors in the nervous system are among the most devastating cancers. This review highlights key advances in understanding the effects of PPARγ ligands in the treatment of tumors in the nervous system.
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Base de dados:
MEDLINE
Assunto principal:
Glioblastoma
/
PPAR gama
/
Meduloblastoma
/
Meningioma
/
Sistema Nervoso
/
Neuroblastoma
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article