Antagonism of quercetin against tremor induced by unilateral striatal lesion of 6-OHDA in rats.
J Asian Nat Prod Res
; 18(1): 65-71, 2016.
Article
em En
| MEDLINE
| ID: mdl-26217978
Quercetin, a flavonoid present in many plants, is reported to be effective in models of neurodegenerative diseases. The aim of the present study was to evaluate the anti-tremor effects of quercetin in 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson's disease. In rats, quercetin had no effect on apomorphine-induced rotations, but it could significantly attenuate muscle tremor of 6-OHDA lesioned rats. Interestingly, quercetin could decrease the burst frequency in a dose- and time-dependent manner. These results suggest that quercetin may have a protective effect on models to mimic muscle tremors of Parkinson's disease. This effect of quercetin may be associated with serotonergic system, but further study is needed.
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MEDLINE
Assunto principal:
Quercetina
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Tremor
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Oxidopamina
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Fármacos Neuroprotetores
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article