Mean platelet volume is associated with disease severity in patients with obstructive sleep apnea syndrome.
Clinics (Sao Paulo)
; 70(7): 481-5, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26222817
ABSTRACT
OBJECTIVE:
Obstructive sleep apnea syndrome is associated with cardiovascular diseases and thromboembolic events. The mean platelet volume (MPV) is a predictor of cardiovascular thromboembolic events. The aim of the present study is to investigate the association between the MPV and disease severity in patients with obstructive sleep apnea syndrome.METHODS:
We prospectively included 194 obstructive sleep apnea syndrome patients without cardiovascular disease (mean age 56.5±12.5 years) who were undergoing sleep tests. An overnight full laboratory polisomnography examination was conducted on each patient. The patients were divided into 3 groups according to the apnea-hypopnea index (AHI) (1) AHIlow group 5≤AHI<15, (2) AHImid group 15RESULTS:
The highest MPV values were found in the AHIhigh group compared with other groups (p<0.05 for all). Multiple linear regression analysis indicated that the MPV was associated with the AHI (ß=0.500, p<0.001) and the high sensitivity C-reactive protein (hs-CRP) level (ß=0.194, p=0.010).CONCLUSION:
The MPV is independently associated with both disease severity and inflammation in patients with obstructive sleep apnea syndrome.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Contagem de Plaquetas
/
Proteína C-Reativa
/
Apneia Obstrutiva do Sono
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article