[Diversity-oriented synthesis and its application in drug discovery].
Yao Xue Xue Bao
; 50(4): 419-33, 2015 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-26223123
ABSTRACT
Diversity-oriented synthesis (DOS) aims to efficiently generate collections of small molecules with diverse appendages, functional groups, stereochemistry and skeletons, thus yielding diverse biological activities capable of modulating a wide variety of biological processes. In this review, we discussed the common strategies employed in DOS with specific examples from recent literature, including reagent-based approach, substrate-based approach, build-couple-pair strategy and privileged substructure-based DOS. The application of some DOS libraries in drug discovery is also presented.
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Base de dados:
MEDLINE
Assunto principal:
Bibliotecas de Moléculas Pequenas
/
Descoberta de Drogas
Idioma:
Zh
Ano de publicação:
2015
Tipo de documento:
Article