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Effects of repeated yohimbine administration on reinstatement of palatable food seeking: involvement of dopamine D1 -like receptors and food-associated cues.
Ball, Kevin T; Miller, Leah; Sullivan, Christopher; Wells, Ashleigh; Best, Olivia; Cavanaugh, Brittany; Copus, Taylor; Corrigan, Nathan; Hawkins, Shaina; Kobbe, Krista; Schoener, Ashley; Steiger, Johnathan; Vieweg, Lauren.
Afiliação
  • Ball KT; Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, PA, USA. kball@bloomu.edu.
  • Miller L; Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, PA, USA.
  • Sullivan C; Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, PA, USA.
  • Wells A; Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, PA, USA.
  • Best O; Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, PA, USA.
  • Cavanaugh B; Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, PA, USA.
  • Copus T; Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, PA, USA.
  • Corrigan N; Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, PA, USA.
  • Hawkins S; Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, PA, USA.
  • Kobbe K; Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, PA, USA.
  • Schoener A; Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, PA, USA.
  • Steiger J; Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, PA, USA.
  • Vieweg L; Department of Psychology, Bloomsburg University of Pennsylvania, Bloomsburg, PA, USA.
Addict Biol ; 21(6): 1140-1150, 2016 11.
Article em En | MEDLINE | ID: mdl-26223161
Acute exposure to the pharmacological stressor yohimbine induces relapse to both food and drug seeking in a rat model. However, no systematic studies on the effects of chronic stress on relapse have been conducted. Because chronic stress causes changes in dopamine D1 -like receptor-mediated transmission in prefrontal cortex (a relapse node), we tested the hypothesis that chronic exposure to stress increases vulnerability to relapse via dopamine-mediated mechanisms. Additionally, to determine the role of food-conditioned cues in reinstatement of food seeking, we made discrete food-paired cues either available (CS Present) or not available (CS Absent) during extinction and reinstatement testing. Rats responded for palatable food reinforcers in daily 3-hour sessions, and the behavior was extinguished. To model chronic stress, rats were injected daily with yohimbine (0.0, 2.5, or 5.0 mg/kg; i.p.) during the first 7 days of extinction. Injections were combined with SCH-23390 (0.0, 5.0, or 10.0 µg/kg; i.p.), a D1 -like receptor antagonist. Rats were then tested for reinstatement of food seeking triggered by acute yohimbine (0.0, 1.0, or 2.0 mg/kg; i.p.) and pellet priming. Rats treated previously with chronic yohimbine displayed increased responding following acute yohimbine priming relative to non-chronically stressed rats, but in the CS Absent condition only. Conversely, the lower dose of chronic yohimbine caused an increase in pellet-primed reinstatement, but this effect was more pronounced in the CS Present condition. Importantly, SCH-23390 combined with repeated yohimbine injections attenuated these effects. Thus, chronic stress may increase vulnerability to relapse under specific circumstances via a dopamine D1 -like receptor-mediated mechanism.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ioimbina / Receptores de Dopamina D1 / Comportamento Alimentar / Antagonistas de Receptores Adrenérgicos alfa 2 / Preferências Alimentares Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ioimbina / Receptores de Dopamina D1 / Comportamento Alimentar / Antagonistas de Receptores Adrenérgicos alfa 2 / Preferências Alimentares Idioma: En Ano de publicação: 2016 Tipo de documento: Article