Advanced Assay Monitoring APP-Carboxyl-Terminal Fragments as Markers of APP Processing in Alzheimer Disease Mouse Models.
Methods Mol Biol
; 1303: 117-23, 2016.
Article
em En
| MEDLINE
| ID: mdl-26235062
ABSTRACT
The 99-amino-acid-long APP-carboxy-terminal fragment, named C99, is a membrane-bound peptide generated from the amyloid precursor protein (APP) by ß-secretase cleavage and is the direct precursor of amyloid beta (Aß). Here we describe a method for the quantification of C99. The amount of C99 is an indicative value of the amyloid pathology in an Alzheimer's disease (AD) model, and could be used as a marker to study AD progression in comprehensive experiments, including screening for new compounds and repurposing of drugs to treat AD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Western Blotting
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Precursor de Proteína beta-Amiloide
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Doença de Alzheimer
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article