Kinetic and Structural Characterization of the Interaction of 6-Methylidene Penem 2 with the ß-Lactamase from Mycobacterium tuberculosis.

Hazra, Saugata; Kurz, Sebastian G; Wolff, Kerstin; Nguyen, Liem; Bonomo, Robert A; Blanchard, John S

Hazra, Saugata; Kurz, Sebastian G; Wolff, Kerstin; Nguyen, Liem; Bonomo, Robert A; Blanchard, John S.

Afiliação

Hazra S; Department of Biotechnology, Indian Institute of Technology, Roorkee , Roorkee, Uttarakhand 247667, India.
Kurz SG; Tufts University School of Medicine , 800 Washington Street, #257, Boston, Massachusetts 02111, United States.
Wolff K; Early Discovery, Infectious Diseases Antibacterial & Antifungal, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
Bonomo RA; Department of Medicine, Louis Stokes Cleveland Veterans Affairs Medical Center , Cleveland, Ohio 44106, United States.
Blanchard JS; Department of Biochemistry, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, New York 10461, United States.

Biochemistry ; 54(36): 5657-64, 2015 Sep 15.

Article em En | MEDLINE | ID: mdl-26237118

Assuntos

Antituberculosos/química; Proteínas de Bactérias/química; Cefalosporinas/química; Mycobacterium tuberculosis/enzimologia; beta-Lactamases/química; Ampicilina/química; Ampicilina/farmacologia; Antituberculosos/farmacologia; Cefalosporinas/farmacologia; Sinergismo Farmacológico; Cinética; Meropeném; Modelos Moleculares; Mycobacterium tuberculosis/efeitos dos fármacos; Tienamicinas/química; Tienamicinas/farmacologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Beta-Lactamases / Cefalosporinas / Mycobacterium tuberculosis / Antituberculosos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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