In vivo endoscopic tissue identification by rapid evaporative ionization mass spectrometry (REIMS).
Angew Chem Int Ed Engl
; 54(38): 11059-62, 2015 Sep 14.
Article
em En
| MEDLINE
| ID: mdl-26248566
ABSTRACT
Gastrointestinal cancers are a leading cause of mortality, accounting for 23 % of cancer-related deaths worldwide. In order to improve outcomes from these cancers, novel tissue characterization methods are needed to facilitate accurate diagnosis. Rapid evaporative ionization mass spectrometry (REIMS) is a technique developed for the inâ
vivo classification of human tissue through mass spectrometric analysis of aerosols released during electrosurgical dissection. This ionization technique was further developed by utilizing surface induced dissociation and was integrated with an endoscopic polypectomy snare to allow inâ
vivo analysis of the gastrointestinal tract. We tested the classification performance of this novel endoscopic REIMS method inâ
vivo. It was shown to be capable of differentiating between healthy layers of the intestinal wall, cancer, and adenomatous polyps based on the REIMS fingerprint of each tissue type inâ
vivo.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Espectrometria de Massas
/
Endoscopia Gastrointestinal
/
Neoplasias Gastrointestinais
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article