Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability.

Schuler, Aaron D; Engles, Courtney A; Maeda, Dean Y; Quinn, Mark T; Kirpotina, Liliya N; Wicomb, Winston N; Mason, S Nicholas; Auten, Richard L; Zebala, John A

Schuler, Aaron D; Engles, Courtney A; Maeda, Dean Y; Quinn, Mark T; Kirpotina, Liliya N; Wicomb, Winston N; Mason, S Nicholas; Auten, Richard L; Zebala, John A.

Afiliação

Schuler AD; Syntrix Biosystems, 215 Clay Street NW, Suite B-5, Auburn, WA 98001, United States. Electronic address: aschuler@syntrixbio.com.
Engles CA; Syntrix Biosystems, 215 Clay Street NW, Suite B-5, Auburn, WA 98001, United States.
Maeda DY; Syntrix Biosystems, 215 Clay Street NW, Suite B-5, Auburn, WA 98001, United States.
Quinn MT; Department of Microbiology and Immunology, Montana State University, 960 Technology Boulevard, Bozeman, MT 59717, United States.
Kirpotina LN; Department of Microbiology and Immunology, Montana State University, 960 Technology Boulevard, Bozeman, MT 59717, United States.
Wicomb WN; Infectious Disease Research Institute, 1616 Eastlake Avenue East, Seattle, WA 98102, United States.
Mason SN; Department of Pediatrics (Neonatal Medicine), DUMC Box 3373, Duke University, Durham, NC 27710, United States.
Auten RL; Department of Pediatrics (Neonatal Medicine), DUMC Box 3373, Duke University, Durham, NC 27710, United States.
Zebala JA; Syntrix Biosystems, 215 Clay Street NW, Suite B-5, Auburn, WA 98001, United States.

Bioorg Med Chem Lett ; 25(18): 3793-7, 2015 Sep 15.

Article em En | MEDLINE | ID: mdl-26248802

Assuntos

Ácidos Borônicos/farmacologia; Niacinamida/análogos & derivados; Receptores de Interleucina-8A/antagonistas & inibidores; Receptores de Interleucina-8B/antagonistas & inibidores; Administração Oral; Disponibilidade Biológica; Ácidos Borônicos/administração & dosagem; Ácidos Borônicos/química; Relação Dose-Resposta a Droga; Humanos; Estrutura Molecular; Niacinamida/administração & dosagem; Niacinamida/química; Niacinamida/farmacologia; Solubilidade; Relação Estrutura-Atividade; Água/química

Palavras-chave

Antagonist; Asthma; COPD; CXCR1; CXCR2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Borônicos / Niacinamida / Receptores de Interleucina-8A / Receptores de Interleucina-8B Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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