Stable Hemiaminals: 2-Aminopyrimidine Derivatives.
Molecules
; 20(8): 14365-76, 2015 Aug 06.
Article
em En
| MEDLINE
| ID: mdl-26258772
ABSTRACT
Stable hemiaminals can be obtained in the one-pot reaction between 2-aminopyrimidine and nitrobenzaldehyde derivatives. Ten new hemiaminals have been obtained, six of them in crystal state. The molecular stability of these intermediates results from the presence of both electron-withdrawing nitro groups as substituents on the phenyl ring and pyrimidine ring, so no further stabilisation by intramolecular interaction is required. Hemiaminal molecules possess a tetrahedral carbon atom constituting a stereogenic centre. As the result of crystallisation in centrosymmetric space groups both enantiomers are present in the crystal structure.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Aminas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article