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Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases.
Lenz, Tobias L; Deutsch, Aaron J; Han, Buhm; Hu, Xinli; Okada, Yukinori; Eyre, Stephen; Knapp, Michael; Zhernakova, Alexandra; Huizinga, Tom W J; Abecasis, Gonçalo; Becker, Jessica; Boeckxstaens, Guy E; Chen, Wei-Min; Franke, Andre; Gladman, Dafna D; Gockel, Ines; Gutierrez-Achury, Javier; Martin, Javier; Nair, Rajan P; Nöthen, Markus M; Onengut-Gumuscu, Suna; Rahman, Proton; Rantapää-Dahlqvist, Solbritt; Stuart, Philip E; Tsoi, Lam C; van Heel, David A; Worthington, Jane; Wouters, Mira M; Klareskog, Lars; Elder, James T; Gregersen, Peter K; Schumacher, Johannes; Rich, Stephen S; Wijmenga, Cisca; Sunyaev, Shamil R; de Bakker, Paul I W; Raychaudhuri, Soumya.
Afiliação
  • Lenz TL; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Deutsch AJ; Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.
  • Han B; Evolutionary Immunogenomics, Department of Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Ploen, Germany.
  • Hu X; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Okada Y; Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.
  • Eyre S; Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Knapp M; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.
  • Zhernakova A; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
  • Huizinga TW; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Boston, Massachusetts, USA.
  • Abecasis G; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Becker J; Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.
  • Boeckxstaens GE; Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Chen WM; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.
  • Franke A; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
  • Gladman DD; Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
  • Gockel I; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Gutierrez-Achury J; Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.
  • Martin J; Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Nair RP; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.
  • Nöthen MM; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
  • Onengut-Gumuscu S; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Boston, Massachusetts, USA.
  • Rahman P; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Rantapää-Dahlqvist S; Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.
  • Stuart PE; Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Tsoi LC; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.
  • van Heel DA; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
  • Worthington J; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  • Wouters MM; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Klareskog L; Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.
  • Elder JT; National Institute for Health Research (NIHR) Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service (NHS) Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.
  • Gregersen PK; Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.
  • Schumacher J; Genetics Department, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
  • Rich SS; Department of Rheumatology, Leiden University Medical Centre, Leiden, the Netherlands.
  • Wijmenga C; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
  • Sunyaev SR; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
  • de Bakker PI; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Raychaudhuri S; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
Nat Genet ; 47(9): 1085-90, 2015 Sep.
Article em En | MEDLINE | ID: mdl-26258845
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Antígenos de Histocompatibilidade Classe I / Antígenos HLA-C / Antígenos HLA-D Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Antígenos de Histocompatibilidade Classe I / Antígenos HLA-C / Antígenos HLA-D Idioma: En Ano de publicação: 2015 Tipo de documento: Article