Plasma cytokine levels in dogs undergoing cardiopulmonary bypass.
Res Vet Sci
; 101: 99-105, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26267098
ABSTRACT
UNLABELLED Currently, there are no reports of inflammatory responses to CPB in dogs. We investigated the time course of pro- and anti-inflammatory cytokine levels during and after CPB. ANIMALS The study group included 11 dogs that underwent mitral valve repair with CPB, and the control group included 7 healthy dogs that underwent ovariohysterectomy. METHODS:
Blood samples from the study group dogs were collected before, during and after surgery and analyzed for plasma levels of interleukin-6 (IL-6), tissue necrosis factor-α (TNF-α), interleukin-10 (IL-10), white blood cells (WBC), and C-reactive protein (CRP). Each inflammatory parameter was also compared with that of the control group dogs.RESULTS:
After CPB, plasma levels of IL-6, WBC counts, and CRP levels were significantly higher than preoperative levels, and IL-6 levels in the study group were significantly higher than those in the control group.CONCLUSIONS:
CPB induces a systemic inflammatory response in dogs.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ponte Cardiopulmonar
/
Citocinas
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Síndrome de Resposta Inflamatória Sistêmica
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Valva Mitral
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article