Causal relationship between delayed gastric emptying and gastroesophageal reflux in patients with neurological impairment.
Pediatr Surg Int
; 31(10): 917-23, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26276427
ABSTRACT
PURPOSE:
To investigate the causal relationship between delayed gastric emptying (DGE) and gastroesophageal reflux (GER) in patients with neurological impairment (NI).METHODS:
Subjects included 30 NI patients (age, 1-34 years; median, 6 years). Combined multichannel intraluminal impedance-pH (MII-pH) monitoring and (13)C-breath test evaluated acid/non-acid reflux episodes (RE) and gastric emptying rates, respectively. Values are shown with medians and ranges.RESULTS:
Percentage time for esophageal pH < 4.0 (reflux index RI) and numbers for total RE and RE > 5 min were 8.3 (0-35.7), 44 (0-129), and 5 (0-22), respectively. Total percentage time and bolus RE numbers were 1.4 (0.0-6.9) and 49 (2-159), respectively. Median bolus clearance time was 16 s (9-45). T 1/2, T lag, and GEC were 103 s (75-204), 54 s (18-97), and 3.4 (2.3-4.3), respectively. Gastric emptying rates and acid/non-acid reflux parameters were not significantly correlated, except T 1/2 correlated significantly with the numbers of RE > 5 min (p = 0.04). T 1/2 inversely correlated with bolus clearance time (p = 0.01). Reflux parameters between DGE and non-DGE patients were not significantly different, except median bolus clearance time was significantly shorter in DGE patients (p = 0.01).CONCLUSIONS:
NI patients showed a wide range of gastric emptying rates without any significant causal relationship between DGE and GER.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Refluxo Gastroesofágico
/
Gastroparesia
/
Doenças do Sistema Nervoso
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article