Matrix Metalloproteinase Mediated Type I Collagen Degradation - An Independent Risk Factor for Mortality in Women.

Dragsbæk, K; Neergaard, J S; Hansen, H B; Byrjalsen, I; Alexandersen, P; Kehlet, S N; Bay-Jensen, A-C; Christiansen, C; Karsdal, M A

Dragsbæk, K; Neergaard, J S; Hansen, H B; Byrjalsen, I; Alexandersen, P; Kehlet, S N; Bay-Jensen, A-C; Christiansen, C; Karsdal, M A.

Afiliação

Dragsbæk K; Nordic Bioscience A/S, Herlev, Denmark.
Neergaard JS; Nordic Bioscience A/S, Herlev, Denmark.
Hansen HB; Nordic Bioscience A/S, Herlev, Denmark.
Byrjalsen I; Nordic Bioscience A/S, Herlev, Denmark.
Alexandersen P; Center for Clinical and Basic Research, Vejle, Denmark.
Kehlet SN; Nordic Bioscience A/S, Herlev, Denmark.
Bay-Jensen AC; Nordic Bioscience A/S, Herlev, Denmark.
Christiansen C; Nordic Bioscience A/S, Herlev, Denmark.
Karsdal MA; Nordic Bioscience A/S, Herlev, Denmark.

EBioMedicine ; 2(7): 723-9, 2015 Jul.

Article em En | MEDLINE | ID: mdl-26288845

Assuntos

Colágeno Tipo I/metabolismo; Metaloproteinases da Matriz/metabolismo; Proteólise; Idoso; Idoso de 80 Anos ou mais; Estudos de Coortes; Intervalos de Confiança; Feminino; Humanos; Estimativa de Kaplan-Meier; Pessoa de Meia-Idade; Mortalidade; Análise Multivariada; Fatores de Risco

Palavras-chave

C1M, MMP-mediated type I collagen degradation; CTX-I, Cathepsin K degraded products of C-terminal telopeptides of type I collagen; Clinical; ECM, Extracellular matrix; Extracellular matrix remodeling; MMP; MMP, Matrix metalloproteinase; Mortality; PERF I, Prospective Epidemiological Risk Factor study; PTM, Post-translational modification; Protease activity; Type I collagen

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metaloproteinases da Matriz / Colágeno Tipo I / Proteólise Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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