Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii.
Org Biomol Chem
; 13(39): 10015-24, 2015 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-26291306
ABSTRACT
A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoan Toxoplasma gondii.
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Base de dados:
MEDLINE
Assunto principal:
Toxoplasma
/
Alcaloides Indólicos
/
Antiprotozoários
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article