Enantioselective Organocatalytic Transfer Hydrogenation of 1,2-Dihydroquinoline through Formation of Aza-o-xylylene.
Org Lett
; 17(17): 4125-7, 2015 Sep 04.
Article
em En
| MEDLINE
| ID: mdl-26301545
ABSTRACT
A new way of forming the aza-o-xylylene with easily accessible 1,2-dihydroquinolines as precursor has been developed. The presence of an electron-donating group at the proper position of 1,2-dihydroquinoline was crucial for protonation of the alkene through dearomatization with a simple Brønsted acid. The in situ forming reactive intermediate was trapped with Hantzsch ester to afford tetrahydroquinolines in excellent yield and enantioselectivity.
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MEDLINE
Idioma:
En
Ano de publicação:
2015
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Article