[Distribution of CD45RO⺠T and CD45RA⺠T Cells in Peripheral Blood of Patients with Peripheral T Cell Lymphoma].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 23(4): 1017-20, 2015 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-26314437
ABSTRACT
OBJECTIVE:
To investigate the clinical significance of memory T cells (CD45RO⺠T) and the initial T cells (CD45RA⺠T) distribution in peripheral blood of patients with peripheral T-cell lymphoma (PTCL).METHODS:
A total of 27 patients diagnosed as PTCL in our hospital from February 2010 to February 2014 were collected in this study; whereas 30 healthy people were enrolled as control. The distribution of CD45RO⺠T and CD45RA⺠T cells were detected seperately in each group, and the results were analysed further.RESULTS:
The expression of T cell antigens in lymphnodes of PTCL patients were diverse the CD4⺠T cells were the main immune phenotype, while the B cell-related antigen was not expressed. The CD4âº/CD8âº, CD4⺠CD45RO⺠T in the peripheral blood of PTCL patients were significantly lower than that in normal group (P < 0.05); while the CD4, CD45RA⺠T, CD8⺠CD45RA⺠T and CD8⺠CD45RO⺠T were significantly higher than that in normal group (P < 0.05). The patients in stage I/II had higher CD4âº/CD8âº, CD4⺠CD45RO⺠T than those in stage III/IV (P < 0.05), whereas the CD4⺠CD45RA⺠T, CD8⺠CD45RA⺠T and CD8⺠CD45RO⺠T were significantly lower than those in the stage III/IV patients (P < 0.05).CONCLUSION:
The distributions of CD45RA⺠T and CD45RO⺠T in PTCL patients are quite different, and the corresponding treatment might be adopted according to the different distribution of these cells, so as to improve the diagnosis and prognosis of PTCL.
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Base de dados:
MEDLINE
Assunto principal:
Linfoma de Células T Periférico
Idioma:
Zh
Ano de publicação:
2015
Tipo de documento:
Article