Differential skin test reactivity to pollens in pollen food allergy syndrome versus allergic rhinitis.
Allergy Asthma Proc
; 36(5): 379-85, 2015.
Article
em En
| MEDLINE
| ID: mdl-26314819
ABSTRACT
BACKGROUND:
Pollen food allergy syndrome (PFAS), also called oral allergy syndrome, is a form of food allergy in which uncooked foods cause allergic symptoms generally limited to the oral mucosa. It occurs in a subset of patients with pollen allergy, although not all patients have prominent rhinitis symptoms. PFAS is related to antigenic similarity between the pollen and food allergen.OBJECTIVE:
The size of skin test reactions in a group of subjects with pollen sensitivity with PFAS was compared with a group of subjects who were pollen sensitive and without PFAS. Self-reported rhinitis symptoms between the two groups were compared to identify if symptom severity differed.METHODS:
Twenty subjects with PFAS and 20 subjects with seasonal allergic rhinitis without PFAS were enrolled in the study. All the subjects underwent standard skin-prick testing to a panel of common allergens, including select fresh fruits and vegetables. The subjects completed a Mini Rhinoconjunctivitis Quality of Life Questionnaire as part of their clinical evaluation. The subjects with PFAS and those without PFAS were compared statistically.RESULTS:
The subjects with PFAS had significantly larger-sized skin-prick test results specific to pollens (p < 0.05). Despite the larger-sized skin-prick test results, the subjects with allergic rhinitis and PFAS reported milder nasal symptoms in relation to pollen skin test result size when compared with allergic rhinitis controls without PFAS.CONCLUSIONS:
Our study outlined basic differences between two seemingly similar patient groups with a particularly striking discordance between skin test result sizes and rhinitis symptoms. This discordance should be explored further to increase mechanistic understanding of allergen cross-reactivity in PFAS.
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Base de dados:
MEDLINE
Assunto principal:
Pólen
/
Testes Cutâneos
/
Rinite Alérgica Sazonal
/
Rinite Alérgica
/
Hipersensibilidade Alimentar
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article