Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes.

Jang, Hyun-Hee; Liu, Jingbao; Lee, Ga-Young; Halpert, James R; Wilderman, P Ross

Jang, Hyun-Hee; Liu, Jingbao; Lee, Ga-Young; Halpert, James R; Wilderman, P Ross.

Afiliação

Jang HH; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, United States.
Liu J; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, United States.
Lee GY; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, United States.
Halpert JR; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, United States.
Wilderman PR; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, United States. Electronic address: ross.wilderman@uconn.edu.

Arch Biochem Biophys ; 584: 61-9, 2015 Oct 15.

Article em En | MEDLINE | ID: mdl-26319176

Assuntos

Hidrocarboneto de Aril Hidroxilases/química; Cumarínicos/química; Citocromo P-450 CYP2B6/química; Substituição de Aminoácidos; Hidrocarboneto de Aril Hidroxilases/genética; Hidrocarboneto de Aril Hidroxilases/metabolismo; Domínio Catalítico; Citocromo P-450 CYP2B6/genética; Citocromo P-450 CYP2B6/metabolismo; Família 2 do Citocromo P450; Humanos; Mutação de Sentido Incorreto; Oxirredução

Palavras-chave

Cytochrome P450; Monooxygenase coupling; Site-directed mutagenesis; Structurefunction relationship

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrocarboneto de Aril Hidroxilases / Cumarínicos / Citocromo P-450 CYP2B6 Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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