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Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.
Canning, Peter; Ruan, Qui; Schwerd, Tobias; Hrdinka, Matous; Maki, Jenny L; Saleh, Danish; Suebsuwong, Chalada; Ray, Soumya; Brennan, Paul E; Cuny, Gregory D; Uhlig, Holm H; Gyrd-Hansen, Mads; Degterev, Alexei; Bullock, Alex N.
Afiliação
  • Canning P; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK.
  • Ruan Q; Department of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
  • Schwerd T; Translational Gastroenterology Unit, Nuffield Department of Medicine and Department of Pediatrics, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.
  • Hrdinka M; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.
  • Maki JL; Department of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
  • Saleh D; Medical Scientist Training Program and Program in Neuroscience, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
  • Suebsuwong C; Department of Chemistry, University of Houston, Houston, TX 77204, USA.
  • Ray S; Center for Neurologic Diseases, Department of Neurology, Brigham & Women's Hospital and Harvard Medical School, Cambridge, MA 02139, USA.
  • Brennan PE; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK; Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford OX3 7LD, UK.
  • Cuny GD; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA.
  • Uhlig HH; Translational Gastroenterology Unit, Nuffield Department of Medicine and Department of Pediatrics, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.
  • Gyrd-Hansen M; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.
  • Degterev A; Department of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA. Electronic address: alexei.degterev@tufts.edu.
  • Bullock AN; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK. Electronic address: alex.bullock@sgc.ox.ac.uk.
Chem Biol ; 22(9): 1174-84, 2015 Sep 17.
Article em En | MEDLINE | ID: mdl-26320862
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Proteína Serina-Treonina Quinase 2 de Interação com Receptor / Proteína Adaptadora de Sinalização NOD1 / Proteína Adaptadora de Sinalização NOD2 Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Proteína Serina-Treonina Quinase 2 de Interação com Receptor / Proteína Adaptadora de Sinalização NOD1 / Proteína Adaptadora de Sinalização NOD2 Idioma: En Ano de publicação: 2015 Tipo de documento: Article