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HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders.
Janes, Holly; Herbeck, Joshua T; Tovanabutra, Sodsai; Thomas, Rasmi; Frahm, Nicole; Duerr, Ann; Hural, John; Corey, Lawrence; Self, Steve G; Buchbinder, Susan P; McElrath, M Juliana; O'Connell, Robert J; Paris, Robert M; Rerks-Ngarm, Supachai; Nitayaphan, Sorachai; Pitisuttihum, Punnee; Kaewkungwal, Jaranit; Robb, Merlin L; Michael, Nelson L; Mullins, James I; Kim, Jerome H; Gilbert, Peter B; Rolland, Morgane.
Afiliação
  • Janes H; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Herbeck JT; Department of Global Health, University of Washington, Seattle, Washington, USA.
  • Tovanabutra S; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
  • Thomas R; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.
  • Frahm N; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
  • Duerr A; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.
  • Hural J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Corey L; Department of Global Health, University of Washington, Seattle, Washington, USA.
  • Self SG; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Buchbinder SP; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • O'Connell RJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Paris RM; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Rerks-Ngarm S; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Nitayaphan S; Department of Global Health, University of Washington, Seattle, Washington, USA.
  • Pitisuttihum P; Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Kaewkungwal J; Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
  • Robb ML; Royal Thai Army Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
  • Michael NL; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
  • Mullins JI; Thai Ministry of Public Health, Nonthaburi, Thailand.
  • Kim JH; Royal Thai Army Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
  • Gilbert PB; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Rolland M; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Nat Med ; 21(10): 1139-41, 2015 Oct.
Article em En | MEDLINE | ID: mdl-26322580
ABSTRACT
Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found--n two different cohorts--hat more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Efeito Fundador / Carga Viral Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Efeito Fundador / Carga Viral Idioma: En Ano de publicação: 2015 Tipo de documento: Article