Melittin, a honeybee venomderived antimicrobial peptide, may target methicillinresistant Staphylococcus aureus.
Mol Med Rep
; 12(5): 6483-90, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26330195
ABSTRACT
Methicillinresistant Staphylococcus aureus (MRSA) is difficult to treat using available antibiotic agents. Honeybee venom has been widely used as an oriental treatment for several inflammatory diseases and bacterial infections. The venom contains predominantly biologically active compounds, however, the therapeutic effects of such materials when used to treat MRSA infections have not been investigated extensively. The present study evaluated bee venom and its principal active component, melittin, in terms of their antibacterial activities and in vivo protection against MRSA infections. In vitro, bee venom and melittin exhibited comparable levels of antibacterial activity, which was more marked against MRSA strains, compared with other Grampositive bacteria. When MRSAinfected mice were treated with bee venom or melittin, only the latter animals were successfully rescued from MRSA induced bacteraemia or exhibited recovery from MRSAinfected skin wounds. Together, the data of the present study demonstrated for the first time, to the best of our knowledge, that melittin may be used as a promising antimicrobial agent to enhance the healing of MRSAinduced wounds.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Estafilocócicas
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Venenos de Abelha
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Peptídeos Catiônicos Antimicrobianos
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Staphylococcus aureus Resistente à Meticilina
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Meliteno
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Antibacterianos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article