Building an integrated model of chromosome congression.
J Cell Sci
; 128(18): 3363-74, 2015 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-26330530
ABSTRACT
A universal feature of mitosis is that all chromosomes become aligned at the spindle equator--the halfway point between the two spindle poles--prior to anaphase onset. This migratory event is called congression, and is powered by centromere-bound protein machines called kinetochores. This Commentary aims to document recent advances concerning the two kinetochore-based force-generating mechanisms that drive mitotic chromosome congression in vertebrate cells depolymerisation-coupled pulling (DCP) and lateral sliding. We aim to explore how kinetochores can 'read-out' their spatial position within the spindle, and adjust these force-generating mechanisms to ensure chromosomes reach, and then remain, at the equator. Finally, we will describe the 'life history' of a chromosome, and provide a working model for how individual mechanisms are integrated to ensure efficient and successful congression.
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Base de dados:
MEDLINE
Assunto principal:
Cinetocoros
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Segregação de Cromossomos
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Pareamento Cromossômico
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Modelos Biológicos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article