Induction of Colon Cancer in Mice with 1,2-Dimethylhydrazine.

Gurley, Kay E; Moser, Russell D; Kemp, Christopher J

Gurley, Kay E; Moser, Russell D; Kemp, Christopher J.

Afiliação

Gurley KE; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.
Moser RD; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.
Kemp CJ; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.

Cold Spring Harb Protoc ; 2015(9): pdb.prot077453, 2015 Sep 01.

Article em En | MEDLINE | ID: mdl-26330619

RESUMO

In this protocol, colon cancer is induced in mice through a series of injections with 1,2-dimethylhydrazine. Mice will develop primarily colon tumors starting at about 3 mo after the first injection. Tumors in the lung, uterus, and small intestine may also be seen, as well as lymphomas.

Assuntos

1,2-Dimetilidrazina/metabolismo; Neoplasias do Colo/induzido quimicamente; 1,2-Dimetilidrazina/administração & dosagem; Animais; Neoplasias do Colo/patologia; Injeções Subcutâneas; Camundongos; Fatores de Tempo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / 1,2-Dimetilidrazina Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / 1,2-Dimetilidrazina Idioma: En Ano de publicação: 2015 Tipo de documento: Article