Using Insulin Infusion Sets in CSII for Longer Than the Recommended Usage Time Leads to a High Risk for Adverse Events: Results From a Prospective Randomized Crossover Study.
J Diabetes Sci Technol
; 9(6): 1292-8, 2015 Sep 03.
Article
em En
| MEDLINE
| ID: mdl-26341262
ABSTRACT
BACKGROUND:
Infusion sets for use with insulin pumps are recommended for use for 2 to 3 days to avoid local skin reactions, for example, to the insulin formulation and preservatives like meta-cresol. However, many patients use the catheters longer for economic reasons. We performed this study to investigate the tolerability of 2-day use of infusion sets in comparison to 4-day use in a real-world setting.METHODS:
This prospective randomized controlled crossover study with 2 × 3-month observation periods was performed with 24 type 1 patients. At baseline, patients were trained on the use of the infusion system (Medtronic /Mio® or inset™ II) and randomized to any of the 2 treatment sequences. Observation parameters included glycemic control, frequency and nature of device-related, and procedure-related adverse events and patient preference.RESULTS:
The per-protocol analysis was performed with 22 patients (5 men, 17 women, age 39 ± 11 years, BMI 27.0 ± 3.5 kg/m2). The number of catheter related adverse events was 290 with 2-day use versus 495 with 4-day use (P < .05). The overall number of treatment related events was 750 with 2-day use versus 934 with 4-day use (P < .001). There was no difference in glycemic control between the treatment arms. Treatment satisfaction was higher with 2-day use (very high/high satisfaction 90.4% versus 4 day-use 77.3%, P < .05).CONCLUSION:
Our results demonstrate that using the infusion sets for a longer usage period of 2-3 days resulted in a clinically relevant increase in treatment-related tolerability problems. Patients should be trained and encouraged not to use insulin pump infusion sets for a longer than the recommended time period.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sistemas de Infusão de Insulina
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Diabetes Mellitus Tipo 1
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Equipamentos Descartáveis
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Catéteres
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Hipoglicemiantes
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Insulina
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article