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Disseminating Melanoma Cells Surf on Calcium Waves.
Sun, Jianwei; Lin, Shengchen; Keeley, Tyler; Yang, Shengyu.
Afiliação
  • Sun J; Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute ; Comprehensive Melanoma Research Center, H. Lee Moffitt Cancer Center and Research Institute.
  • Lin S; Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute ; Comprehensive Melanoma Research Center, H. Lee Moffitt Cancer Center and Research Institute.
  • Keeley T; Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute ; Comprehensive Melanoma Research Center, H. Lee Moffitt Cancer Center and Research Institute.
  • Yang S; Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute ; Comprehensive Melanoma Research Center, H. Lee Moffitt Cancer Center and Research Institute.
Mol Cell Oncol ; 2(4)2015.
Article em En | MEDLINE | ID: mdl-26346228
ABSTRACT
Dysregulated calcium signaling has been increasingly implicated in tumor dissemination and progression. In a recent study we investigated the mechanism underlying calcium-mediated melanoma invasion and metastasis, and discovered that hyperactive Ca2+ oscillation in melanoma cells promoted invasion and metastasis through promoting invadopodium formation and extracellular matrix remodeling.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article