Hypoxia Promotes Synergy between Mitomycin C and Bortezomib through a Coordinated Process of Bcl-xL Phosphorylation and Mitochondrial Translocation of p53.

Song, Xinxin; Dilly, Ashok-Kumar; Choudry, Haroon Asif; Bartlett, David L; Kwon, Yong Tae; Lee, Yong J

Song, Xinxin; Dilly, Ashok-Kumar; Choudry, Haroon Asif; Bartlett, David L; Kwon, Yong Tae; Lee, Yong J.

Afiliação

Song X; Department of Surgery, University of Pittsburgh Cancer Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Dilly AK; Department of Surgery, University of Pittsburgh Cancer Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Choudry HA; Department of Surgery, University of Pittsburgh Cancer Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Bartlett DL; Department of Surgery, University of Pittsburgh Cancer Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Kwon YT; Protein Metabolism Medical Research Center and Department of Biomedical Science, College of Medicine, Seoul National University, Seoul, Korea.
Lee YJ; Department of Surgery, University of Pittsburgh Cancer Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

Mol Cancer Res ; 13(12): 1533-43, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26354682

Assuntos

Antineoplásicos/administração & dosagem; Bortezomib/administração & dosagem; Neoplasias Colorretais/tratamento farmacológico; Mitomicina/administração & dosagem; Proteína Supressora de Tumor p53/metabolismo; Proteína bcl-X/metabolismo; Animais; Antineoplásicos/farmacologia; Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem; Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Bortezomib/farmacologia; Hipóxia Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Neoplasias Colorretais/metabolismo; Sinergismo Farmacológico; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Camundongos; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Mitomicina/farmacologia; Fosforilação/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteína Supressora de Tumor p53 / Mitomicina / Proteína bcl-X / Bortezomib / Antineoplásicos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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