Cancer stem cell marker phenotypes are reversible and functionally homogeneous in a preclinical model of pancreatic cancer.

Dosch, Joseph S; Ziemke, Elizabeth K; Shettigar, Amrith; Rehemtulla, Alnawaz; Sebolt-Leopold, Judith S

Dosch, Joseph S; Ziemke, Elizabeth K; Shettigar, Amrith; Rehemtulla, Alnawaz; Sebolt-Leopold, Judith S.

Afiliação

Dosch JS; Translational Oncology Program, University of Michigan Medical School, Ann Arbor, Michigan. Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan.
Ziemke EK; Translational Oncology Program, University of Michigan Medical School, Ann Arbor, Michigan. Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan.
Shettigar A; Translational Oncology Program, University of Michigan Medical School, Ann Arbor, Michigan. Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan.
Rehemtulla A; Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan. Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan.
Sebolt-Leopold JS; Translational Oncology Program, University of Michigan Medical School, Ann Arbor, Michigan. Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan. jssl@med.umich.edu.

Cancer Res ; 75(21): 4582-92, 2015 Nov 01.

Article em En | MEDLINE | ID: mdl-26359451

Assuntos

Neoplasias Experimentais/patologia; Células-Tronco Neoplásicas/patologia; Neoplasias Pancreáticas/patologia; Proteínas Proto-Oncogênicas p21(ras)/genética; Proteína Supressora de Tumor p53/genética; Antígeno AC133; Animais; Antígenos CD/metabolismo; Antígenos Ly/metabolismo; Antimetabólitos Antineoplásicos/farmacologia; Biomarcadores Tumorais/genética; Antígeno CD24/metabolismo; Transformação Celular Neoplásica; Desoxicitidina/análogos & derivados; Desoxicitidina/farmacologia; Modelos Animais de Doenças; Glicoproteínas/metabolismo; Luciferases/metabolismo; Proteínas de Membrana/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Neoplasias Experimentais/genética; Pâncreas/patologia; Neoplasias Pancreáticas/genética; Peptídeos/metabolismo; Fenótipo; Piranos/farmacologia; Esferoides Celulares; Coloração e Rotulagem; Células Tumorais Cultivadas; Gencitabina

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Células-Tronco Neoplásicas / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas p21(ras) / Neoplasias Experimentais Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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